What is 1-[(9H-fluoren-9-ylmethoxy)carbonyl]oxy]pyrrolidine-2,5-dione (Fmoc-Pyr-OH)?

Fmoc-Pyr-OH, also known as Fmoc-protected pyrrolidine-2,5-dione, is a common building block used in peptide synthesis. It consists of a pyrrolidine-2,5-dione core with a fluorenylmethoxycarbonyl (Fmoc) protecting group attached to one of the nitrogen atoms. This compound is widely used in solid-phase peptide synthesis due to its stability and ease of cleavage.

What are the key features of Fmoc-Pyr-OH?

- Fmoc-Pyr-OH is a versatile building block for peptide synthesis.
- The Fmoc protecting group can be easily removed under mild conditions.
- This compound is compatible with standard Fmoc solid-phase peptide synthesis protocols.
- Fmoc-Pyr-OH offers high purity and excellent quality for reliable peptide synthesis.
- It is available in bulk quantities for research and development purposes.

How is Fmoc-Pyr-OH used in peptide synthesis?

Fmoc-Pyr-OH is typically attached to a solid support resin to initiate peptide elongation. The Fmoc protecting group blocks the amine functionality of the pyrrolidine-2,5-dione, allowing for selective deprotection and coupling reactions with other amino acids. After chain assembly is complete, the Fmoc group is removed to expose the amine for further peptide elongation or cleavage from the resin.

What are the advantages of using Fmoc-Pyr-OH in peptide synthesis?

- Fmoc-Pyr-OH provides high chemical stability during peptide assembly.
- The Fmoc protecting group can be easily removed without affecting peptide integrity.
- This compound offers efficient coupling reactions with minimal side reactions.
- Fmoc-Pyr-OH is compatible with a wide range of amino acids and peptide sequences.
- Its high purity and solubility make it ideal for complex peptide synthesis.

Where can I purchase Fmoc-Pyr-OH for my research needs?

Fmoc-Pyr-OH is available from various chemical suppliers and distributors worldwide. If you are looking to purchase this compound in bulk quantities for your peptide synthesis projects, you can reach out to reputable suppliers specializing in custom peptide synthesis reagents. Be sure to inquire about product specifications, quality control measures, and pricing options to meet your research requirements.