Taiy Chemical
cis-5-Fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid
Product Name Sulindac
Synonyms:28204 (Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid; 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-, (Z)-; Aflodac; Algocetil; Arthrocine; Artribid; BRN 2951842; CCRIS 3305; Citireuma; Clinoril; Clisundac; Imbaral; MK 231; Mobilin; Reumofil; Sudac; Sulindac sulfoxide; Sulindaco; Sulindacum; Sulinol; Sulreuma; UNII-184SNS8VUH; cis-5-Fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid; cis-5-Fluoro-2-methyl-1-((p-methylsulfinyl)benzylidene)indene-3-acetic acid; cis-5-Fluoro-2-methyl-1-((p-methylsulfinyl)benzylidenyl)indene-3-acetic acid; cis-Sulindac; {5-fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]-1H-inden-3-yl}acetic acid; {(1E)-5-fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]-1H-inden-3-yl}acetic acid
CAS RN. 38194-50-2
EINECS 253-819-2
Molecular Weight 356.4106
Molecular Formula C20H17FO3S
Density 1.38g/cm3
Boiling Point(℃) 581.6°C at 760 mmHg
Flash Point(℃) 305.6°C
refractive_index 1.672
Hazard Symbols Xn Details
Xn
Risk Codes  R22;    Details
 R22;     Details
Safety Description  AddDetails
 Add Details
FAQ
What is cis-5-Fluoro-2-methyl-1-(4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid?
cis-5-Fluoro-2-methyl-1-(4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid is a compound that belongs to the class of indene acetic acids. It is a potent and selective matrix metalloproteinase-13 (MMP-13) inhibitor, which makes it a promising candidate for the treatment of osteoarthritis.

How does cis-5-Fluoro-2-methyl-1-(4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid work?
cis-5-Fluoro-2-methyl-1-(4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid works by inhibiting the activity of MMP-13, an enzyme that plays a key role in the degradation of cartilage in joints. By blocking MMP-13, this compound helps to preserve cartilage integrity and reduce the progression of osteoarthritis.

What are the potential benefits of using cis-5-Fluoro-2-methyl-1-(4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid?
Some potential benefits of using cis-5-Fluoro-2-methyl-1-(4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid include:
- Preservation of cartilage integrity
- Reduction of joint pain and inflammation
- Improvement in joint function and mobility
- Slowing down the progression of osteoarthritis
- Fewer side effects compared to traditional osteoarthritis treatments

Is cis-5-Fluoro-2-methyl-1-(4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid safe for use?
cis-5-Fluoro-2-methyl-1-(4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid has shown promising safety profiles in preclinical studies. However, further clinical trials are needed to evaluate its safety and efficacy in humans. It is important to consult with a healthcare professional before using this compound, especially if you have any underlying medical conditions or are taking other medications.

Are there any side effects associated with the use of cis-5-Fluoro-2-methyl-1-(4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid?
While cis-5-Fluoro-2-methyl-1-(4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid has shown promising safety profiles in preclinical studies, there may be potential side effects associated with its use. Some possible side effects may include gastrointestinal upset, allergic reactions, or interactions with other medications. It is essential to closely monitor for any adverse reactions and consult with a healthcare professional if you experience any concerning symptoms.

Overall, cis-5-Fluoro-2-methyl-1-(4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid shows great promise as a potential treatment for osteoarthritis by targeting MMP-13 activity and preserving cartilage integrity. However, further research is needed to fully understand its safety and efficacy in humans. If you're considering using this compound, make sure to consult with your healthcare provider to discuss the potential benefits and risks for your specific situation.
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